Skip to Main content Skip to Navigation
Journal articles

Mass Cytometry Identifies Expansion of T-bet(+) B Cells and CD206(+) Monocytes in Early Multiple Sclerosis

Abstract : Multiple sclerosis (MS) is an immune-driven demyelinating disease of the central nervous system. Immune cell features are particularly promising as predictive biomarkers due to their central role in the pathogenesis but also as drug targets, even if nowadays, they have no impact in clinical practice. Recently, high-resolution approaches, such as mass cytometry (CyTOF), helped to better understand the diversity and functions of the immune system. In this study, we performed an exploratory analysis of blood immune response profiles in healthy controls and MS patients sampled at their first neurological relapse, using two large CyTOF panels including 62 markers exploring myeloid and lymphoid cells. An increased abundance of both a T-bet-expressing B cell subset and a CD206(+) classical monocyte subset was detected in the blood of early MS patients. Moreover, T-bet-expressing B cells tended to be enriched in aggressive MS patients. This study provides new insights into understanding the pathophysiology of MS and the identification of immunological biomarkers. Further studies will be required to validate these results and to determine the exact role of the identified clusters in neuroinflammation.
Complete list of metadata

https://hal.archives-ouvertes.fr/hal-03260876
Contributor : Xavier Chard-Hutchinson <>
Submitted on : Tuesday, June 15, 2021 - 11:33:14 AM
Last modification on : Monday, June 21, 2021 - 5:27:59 PM

File

pdf
Publisher files allowed on an open archive

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Citation

Laura Couloume, Juliette Ferrant, Simon Le Gallou, Marion Mandon, Rachel Jean, et al.. Mass Cytometry Identifies Expansion of T-bet(+) B Cells and CD206(+) Monocytes in Early Multiple Sclerosis. Frontiers in Immunology, Frontiers, 2021, 12, pp.653577. ⟨10.3389/fimmu.2021.653577⟩. ⟨hal-03260876⟩

Share

Metrics

Record views

24

Files downloads

22