Degradation of Single-Layer and Few-Layer Graphene by Neutrophil Myeloperoxidase

Rajendra Kurapati (1) , Sourav Mukherjee (2) , Cristina Martin (1, 3) , George Bepete (4) , Ester Vázquez (5) , Alain Pénicaud (4) , Bengt Fadeel (2) , Alberto Bianco (6)

1 ICT - Immunopathologie et chimie thérapeutique
2 Karolinska Institutet [Stockholm]
3 IRICA - Instituto Regional de Investigacion Cientifica Aplicada
4 CRPP - Centre de Recherche Paul Pascal
5 IRICA - Instituto Regionalde Investigacion Cientifica Aplicada
6 ICT - Immunologie et chimie thérapeutiques

Biodegradability of graphene is one of the fundamental parameters determining the fate of this material in vivo. Two types of aqueous dispersible graphene, corresponding to single‐layer (SLG) and few‐layer graphene (FLG), devoid of either chemical functionalization or stabilizing surfactants, were subjected to biodegradation by human myeloperoxidase (hMPO) mediated catalysis. Graphene biodegradation was also studied in the presence of activated, degranulating human neutrophils. The degradation of both FLG and SLG sheets was confirmed by Raman spectroscopy and electron microscopy analyses, leading to the conclusion that highly dispersed pristine graphene is not biopersistent.

Mots clés: Graphenide solution; Transition metal oxide nanoparticle; Synthesis; Catalysis; Material chemistry

Domaines: Matériaux; Catalyse

Rajendra Kurapati, Sourav Mukherjee, Cristina Martin, George Bepete, Ester Vázquez, et al.. Degradation of Single-Layer and Few-Layer Graphene by Neutrophil Myeloperoxidase. Angewandte Chemie International Edition, 2018, 57 (36), pp.11722-11727. ⟨10.1002/anie.201806906⟩. ⟨hal-02179368⟩