Matrix to predict rapid radiographic progression of early rheumatoid arthritis patients from the community treated with methotrexate or leflunomide: results from the ESPOIR cohort

Bruno Fautrel (1) , Benjamin Granger (1) , Bernard Combe (2, 3) , Alain Saraux (4) , Francis Guillemin (5, 6) , Xavier Le Loet (7, 8)

1 GRC-08 EEMOIS - Épidémiologie et Évaluation des Maladies Ostéoarticulaires Inflammatoires et Systémiques
2 IGMM - Institut de Génétique Moléculaire de Montpellier
3 Service de rhumatologie
4 Service de rhumatologie
5 APEMAC - Maladies chroniques, santé perçue, et processus d'adaptation
6 Centre d'Investigation Clinique - Epidemiologie Clinique/essais Cliniques Nancy
7 Service de Rhumatologie [CHU Rouen]
8 Physiopathologie et biothérapies des maladies inflammatoires et autoimmunes

Introduction
Early rheumatoid arthritis (RA) patients may show rapid radiographic progression (RRP) despite rapid initiation of synthetic disease-modifying anti-rheumatic drugs (DMARDs). The present study aimed to develop a matrix to predict risk of RRP despite early DMARD initiation in real life settings.
Methods
The ESPOIR cohort included 813 patients from the community with early arthritis for < 6 months; 370 patients had early RA and had received methotrexate or leflunomide during the first year of follow-up. RRP was defined as an increase in the van der Heijde-modified Sharp score (vSHS) ≥ 5 points at 1 year. Determinants of RRP were examined first by bivariate analysis, then multivariate stepwise logistic regression analysis. A visual matrix model was then developed to predict RRP in terms of patient baseline characteristics.
Results
We analyzed data for 370 patients. The mean Disease Activity Score in 28 joints was 5.4 ± 1.2, 18.1% of patients had typical RA erosion on radiographs and 86.4% satisfied the 2010 criteria of the American College of Rheumatology/European League Against Rheumatism. During the first year, mean change in vSHS was 1.6 ± 5.5, and 41 patients (11.1%) showed RRP. A multivariate logistic regression model enabled the development of a matrix predicting RRP in terms of baseline swollen joint count, C-reactive protein level, anti-citrullinated peptide antibodies status, and erosions seen on radiography for patients with early RA who received DMARDs.
Conclusions
The ESPOIR matrix may be a useful clinical practice tool to identify patients with early RA at high risk of RRP despite early DMARD initiation.

Domaines: Rhumatologie et système ostéo-articulaire

Bruno Fautrel, Benjamin Granger, Bernard Combe, Alain Saraux, Francis Guillemin, et al.. Matrix to predict rapid radiographic progression of early rheumatoid arthritis patients from the community treated with methotrexate or leflunomide: results from the ESPOIR cohort. Arthritis Research and Therapy, 2012, 14 (6), pp.R249. ⟨10.1186/ar4092⟩. ⟨inserm-00769662⟩