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Easy and effective method to produce functionalized particles for cellular uptake

Abstract : In this contribution, a versatile approach for the synthesis of functionalized particles for drug delivery is presented, using two nonaggressive standardized procedures. The first procedure considered is the functionalization of an azido-terminated α-norbornenyl poly(ethylene oxide) (PEO) macromonomer with an alkyne-containing active molecule via the copper catalyzed azide alkyne cycloaddition, click type reaction. The functionalized macromonomer is then polymerized by Ring-Opening Metathesis Polymerization (ROMP) in dispersion to form functionalized particles. The second procedure consists in synthesizing particles by ROMP in dispersed media of norbornene with azido-terminated α-norbornenyl PEO macromonomer. The ROMP was initiated by the first generation Grubbs catalyst. Such functionalized core-shell particles have stealthy properties due to their PEO shell and can be viewed as universal nanocarriers on which any alkyne-modified active molecule can be grafted by click chemistry. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2013
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Submitted on : Thursday, November 29, 2012 - 3:37:20 PM
Last modification on : Monday, March 28, 2022 - 1:02:04 PM

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Floraine Collette, Régis Delatouche, Christophe Blanquart, Fabien Gueugnon, Marc Gregoire, et al.. Easy and effective method to produce functionalized particles for cellular uptake. Journal of Polymer Science Part A: Polymer Chemistry, Wiley, 2012, 51 (1), pp.176-189. ⟨10.1002/pola.26357⟩. ⟨hal-00758913⟩



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