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Double umbilical cord blood transplantation for hematological malignancies: a long- term analysis from the SFGM-TC registry.

Hélène Labussière Wallet Mohamad Sobh Stéphane Morisset 1 Marie Robin 2 Nathalie Fegueux 3 Sabine Fürst Mohamad Mohty 4 Eric Deconinck 5 Loïc Fouillard 6 Pierre Bordigoni 7 Bernard Rio 8 Anne Sirvent Marc Renaud 8 Nathalie Dhedin Reza Tabrizi 9 Sébastien Maury Agnès Buzyn 10 Gérard Michel Natacha Maillard 11 Jean-Yves Cahn 12 Jacques-Olivier Bay 13 Ibrahim Yacoub-Agha Anne Huynh 14 Aline Schmidt-Tanguy 4 Thierry Lamy 15 Bruno Lioure 16 Nicole Raus 17 Evelyne Marry Federico Garnier 18 Marie-Lorraine Balère Eliane Gluckman 19 Vanderson Rocha Gérard Socié 2 Didier Blaise 9 Noël Milpied 20 Mauricette Michallet 17 
Abstract : : Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for many hematological malignancies for which umbilical cord blood (UCB) represents an alternative source of HSC. In order to overcome the low cellularity of one UCB unit, double UCBT (dUCBT) has been developed in adults. We have analyzed the outcome of 136 patients who underwent dUCBT reported to the SFGM-TC registry between 2005 and 2007. Forty-six patients received myeloablative and 90 reduced intensity conditioning regimens. There were 84 leukemias, 17 NHL, 11 myelomas and 24 other hematological malignancies. At transplantation, 40 (29%) patients were in CR1. At day 60 after transplantation, the cumulative incidence of neutrophil recovery was 91%. We observed one UCB unit domination in 88% of cases. The cumulative incidence of day 100 aGVHD, cGVHD, TRM and relapse at 2 years were 36%, 23%, 27% and 28% respectively. After a median follow-up of 49.5 months, the 3 years probabilities of overall and progression-free survival were 41% and 35% respectively with a significant OS advantage when male cord engrafted male recipients. We obtained a long term plateau among patients in CR1 which makes dUCBT a promising treatment strategy for these patients.
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Contributor : Marie-Claire Dagher Connect in order to contact the contributor
Submitted on : Wednesday, July 31, 2013 - 4:02:54 PM
Last modification on : Friday, November 18, 2022 - 4:12:04 AM

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Hélène Labussière Wallet, Mohamad Sobh, Stéphane Morisset, Marie Robin, Nathalie Fegueux, et al.. Double umbilical cord blood transplantation for hematological malignancies: a long- term analysis from the SFGM-TC registry.. Experimental Hematology, 2013, 41 (11), pp.924-933. ⟨10.1016/j.exphem.2013.05.297⟩. ⟨hal-00849674⟩



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