The outcome of reduced intensity allogeneic stem cell transplantation and autologous stem cell transplantation when performed as a first transplant strategy in relapsed follicular lymphoma: an analysis from the Lymphoma Working Party of the EBMT. - Centre de recherche en cancérologie Nantes-Angers Unité Mixte de Recherche 892 Inserm - 6299 CNRS Accéder directement au contenu
Article Dans Une Revue Bone Marrow Transplantation Année : 2013

The outcome of reduced intensity allogeneic stem cell transplantation and autologous stem cell transplantation when performed as a first transplant strategy in relapsed follicular lymphoma: an analysis from the Lymphoma Working Party of the EBMT.

S. P. Robinson
  • Fonction : Auteur
C. Canals
  • Fonction : Auteur
J. J. Luang
  • Fonction : Auteur
C. Crawley
  • Fonction : Auteur
J. Y. Cahn
  • Fonction : Auteur
D. Pohlreich
  • Fonction : Auteur
M. Gilleece
  • Fonction : Auteur
M. Attal
  • Fonction : Auteur
  • PersonId : 944589
S. Maury
A. Rambaldi
  • Fonction : Auteur
J. Maertens
  • Fonction : Auteur
S. Capria
  • Fonction : Auteur
P. Colombat
  • Fonction : Auteur
S. Montoto
  • Fonction : Auteur
A. Sureda
  • Fonction : Auteur

Résumé

Both auto-SCT and reduced intensity allo-SCT (RIST) are employed in the treatment of relapsed follicular lymphoma (FL). We have analysed the outcome of these two transplant procedures when used as a first transplant in this setting. We conducted a retrospective comparison of 726 patients who underwent an auto-SCT and 149 who underwent a RIST as a first transplant procedure for relapsed FL as reported to the Lymphoma Working Party of the European Bone Marrow Transplant. The non-relapse mortality (NRM) was significantly worse for patients undergoing a RIST (relative risk (RR) 4.0, P<0.001). The 1-year NRM was 15% for those undergoing a RIST compared with 3% for those undergoing an auto-SCT. Disease relapse or progression were significantly worse for those receiving an auto-SCT (RR 3.1, P<0.001). Patients undergoing a RIST had a 5-year relapse rate of 20% compared with 47% for those undergoing an auto-SCT. The PFS at 5 years was 57% for patients receiving a RIST compared with 48% for those receiving an auto-SCT. There was no significant difference in OS between the two groups. RIST is associated with a higher NRM and lower relapse rate in patients with relapsed FL.Bone Marrow Transplantation advance online publication, 17 June 2013; doi:10.1038/bmt.2013.83.

Domaines

Cancer
Fichier non déposé

Dates et versions

hal-00849676 , version 1 (31-07-2013)

Identifiants

Citer

S. P. Robinson, C. Canals, J. J. Luang, H. Tilly, C. Crawley, et al.. The outcome of reduced intensity allogeneic stem cell transplantation and autologous stem cell transplantation when performed as a first transplant strategy in relapsed follicular lymphoma: an analysis from the Lymphoma Working Party of the EBMT.. Bone Marrow Transplantation, 2013, 48, pp.1409-1414. ⟨10.1038/bmt.2013.83⟩. ⟨hal-00849676⟩
1531 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More