Comparative transcriptional profiling of human merkel cells and merkel cell carcinoma

Nicolas Mouchet (1) , Nolwenn Coquart (2, 3) , Nicolas Lebonvallet (4) , Christelle Le Gall-Ianotto (4) , Ariane Mogha (1) , Alain Fautrel (5) , Nicholas Boulais (6) , Brigitte Dréno (7) , Ludovic Martin (8) , Weiguo Hu , Marie-Dominique Galibert (1) , Laurent Misery (4, 9)

1 IGDR - Institut de Génétique et Développement de Rennes
2 Service de dermatologie
3 Facteurs nerveux et structuration tissulaire
4 LNB - Laboratoire de Neurosciences de Brest
5 Hépatotoxicité et xénobiotiques
6 Laboratoire d'Anatomie Pathologique
7 CRCNA - Centre de Recherche en Cancérologie Nantes-Angers
8 Département de dermatologie, CHU Angers
9 Service de dermatologie

Merkel cell carcinoma (MCC) is a rare and aggressive type of skin cancer that is predominantly caused by infection by the Merkel cell polyomavirus. The cell of origin for MCC is still debated because conflicting data suggest that MCC cells could be derived from Merkel cells (MCs) [1] or their precursors [2]. aggressive carcinoma characteristically occurs on sun-exposed areas of elderly white and immunosupressed patients, with approximately 50% of all tumors occuring on the face and neck and 40% in the extremities [3]. This article is protected by copyright. All rights reserved.

Domaines: Génétique

Nicolas Mouchet, Nolwenn Coquart, Nicolas Lebonvallet, Christelle Le Gall-Ianotto, Ariane Mogha, et al.. Comparative transcriptional profiling of human merkel cells and merkel cell carcinoma. Experimental Dermatology, 2014, 23 (12), pp.928-930. ⟨10.1111/exd.12546⟩. ⟨hal-01068392⟩