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Article Dans Une Revue Bone Marrow Transplantation Année : 2018

The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation

Stefan O. Ciurea
  • Fonction : Auteur
Kai Cao
  • Fonction : Auteur
Marcelo Fernadez-Vina
  • Fonction : Auteur
Piyanuch Kongtim
  • Fonction : Auteur
Monzr Al Malki
  • Fonction : Auteur
Ephraim Fuchs
  • Fonction : Auteur
Leo Luznik
  • Fonction : Auteur
Xiao-Jun Huang
Massimo Martelli
  • Fonction : Auteur
Rupert Handgretinger
  • Fonction : Auteur
Denis-Claude Roy
  • Fonction : Auteur
Paul O'Donnell
  • Fonction : Auteur
Asad Bashey
  • Fonction : Auteur
Hillard M. Lazarus
  • Fonction : Auteur
Karen Ballen
  • Fonction : Auteur
Bipin N. Savani
  • Fonction : Auteur

Résumé

Haploidentical donors are now increasingly considered for transplantation in the absence of HLA-matched donors or when an urgent transplant is needed. Donor-specific anti-HLA antibodies (DSA) have been recently recognized as an important barrier against successful engraftment of donor cells, which can affect transplant survival. DSA appear more prevalent in this type of transplant due to higher likelihood of alloimmunization of multiparous females against offspring's HLA antigens, and the degree of mismatch. Here we summarize the evidence for the role of DSA in the development of primary graft failure in haploidentical transplantation and provide consensus recommendations from the European Society for Blood and Marrow Transplant Group on testing, monitoring, and treatment of patients with DSA receiving haploidentical hematopoietic progenitor cell transplantation.

Dates et versions

hal-02143577 , version 1 (29-05-2019)

Identifiants

Citer

Stefan O. Ciurea, Kai Cao, Marcelo Fernadez-Vina, Piyanuch Kongtim, Monzr Al Malki, et al.. The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation. Bone Marrow Transplantation, 2018, 53 (5), pp.521-534. ⟨10.1038/s41409-017-0062-8⟩. ⟨hal-02143577⟩
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