Ovarian and peritoneal psammocarcinoma: Results of a multicenter study on 25 patients

Jean-Baptiste Delhorme (1) , Jordan Ohayon , Sébastien Gouy (2, 3, 4) , Catherine Genestie (5, 6) , Léopold Gaichies (7) , Philippe Morice (2, 3) , Charles Honoré (2, 8) , Julio Abba , Karine Abboud (9) , Mohammad Alyami (10) , Catherine Arvieux (11) , Gerlinde Averous (12) , Naoual Bakrin (10) , Gisèle Balagué , Vincent Barrau , Houda Ben Rejeb , Jean-Marc Bereder (13) , Isabelle Berton-Rigaud , Frédéric Bibeau (14) , Isabelle Bonnefoy , Dominique Bouzard , Ivan Bricault (11) , Cécile Brigand (1) , Sebastien Carrere (15) , Cécile de Chaisemartin (16) , Madleen Chassang (17) , Anne Chevallier , Thomas Courvoisier (18) , Peggy Dartigues (6) , Anthony Dohan (19) , Julien Dubreuil , Frédéric Dumont (20) , Clarisse Eveno (21) , Marie Faruch-Bilfeld (22) , Gwenaël Ferron (23) , Juliette Fontaine , Laure Fournier (24) , Johan Gagnière (25) , Delphine Geffroy , Laurent Ghouti , François-Noël Gilly (26) , Laurence Gladieff (23) , Olivier Glehen (27) , Diane Goéré (28, 2) , Aymeric Guibal , Jean-Marc Guilloit (29) , Frédéric Guyon , Bruno Heyd (30) , Christine Hoeffel (31) , Constance Hordonneau (32) , Sylvie Isaac (27) , Peggy Jourdan-Enfer , Rachid Kaci (33) , Reza Kianmanesh (31) , Catherine Labbe-Devilliers (34) , Joëlle Lacroix (35) , Bernard Lelong (36) , Agnès Leroux-Broussier , Yoann Lherm , Réa Lo Dico (37) , Gérard Lorimier (38) , Caroline Malhaire (39) , Frédéric Marchal (40) , Pascale Mariani (41) , Emilie Mathiotte , Pierre Méeus (42) , Eliane Mery (23) , Simon Msika (43) , Cédric Nadeau (44) , Pablo Ortega-Deballon (45) , Guillaume Passot (26) , Olivier Pellet , Patrice Peyrat (42) , Denis Pezet (25) , Nicolas Pirro (46) , Marc Pocard , Flora Poizat (47) , Jack Porcheron (48) , Anaïs Poulet (49) , François Quenet (50) , Patrick Rat (51) , Pierre Rousselot (52) , Pascal Rousset (53) , Hélène Senellart (54) , Martine Serrano , Vincent Servois (55) , Olivia Sgabura , Andrea Skanjeti (56) , Magali Svrcek (57) , Raphaël Tetreau (58) , Emilie Thibaudeau (34) , Yann Touchefeu (59) , Jean-Jacques Tuech (60) , Séverine Valmary-Degano (61) , Delphine Vaudoyer (27) , Stéphane Velasco (62) , Véronique Verriele-Beurrier , Laurent Villeneuve (63) , Romuald Wernert (34) , Franck Zinzindohoué (64)

1 Département de chirurgie générale et digestive [CHU Strasbourg]
2 IGR - Institut Gustave Roussy
3 Département de chirurgie gynécologique [Gustave Roussy]
4 RaMo-IT - Radiothérapie Moléculaire et Innovation Thérapeutique
5 CHU Pitié-Salpêtrière [AP-HP]
6 Département de biologie et pathologie médicales [Gustave Roussy]
7 UNICAEN Santé - Université de Caen Normandie - UFR Santé
8 Département de chirurgie viscérale [Gustave Roussy]
9 CHU ST-E - Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
10 Service d'Oncologie Médicale [Centre hospitalier Lyon Sud - HCL]
11 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
12 Hôpitaux Universitaires de Strasbourg
13 UNICANCER/CAL - Centre de Lutte contre le Cancer Antoine Lacassagne [Nice]
14 Laboratoire d'anatomo-pathologie
15 Département de chirurgie
16 IPC - Institut Paoli-Calmettes
17 COMUE UCA - COMUE Université Côte d'Azur (2015-2019)
18 CHU de Poitiers - Centre hospitalier universitaire de Poitiers = Poitiers University Hospital
19 Department of Body and Interventional Imaging, Hôpital Lariboisière, Paris, France.
20 Université de Lille
21 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
22 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
23 Institut Claudius Regaud
24 HEGP - Hôpital Européen Georges Pompidou [APHP]
25 Chirurgie digestive et hépatobiliaire
26 EA3738 - Ciblage thérapeutique en Oncologie
27 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
28 Département de chirurgie générale [Gustave Roussy]
29 UNICANCER/CRLC - Centre Régional de Lutte contre le Cancer François Baclesse [Caen]
30 Service de chirurgie viscérale et digestive - Unité de transplantation hépatique
31 Hôpital universitaire Robert Debré [Reims]
32 Service de Radiologie
33 Service de pathologie
34 UNICANCER/ICO - Institut de Cancérologie de l'Ouest [Angers/Nantes]
35 Service de Radiologie [CLCC Baclesse]
36 CRT - Centre de recherches
37 Service de Chirurgie d'Oncologie Digestive [CHU Lariboisière]
38 CRLCC Paul Papin - CRLCC - Centre Paul Papin
39 Hôpital Henri Mondor
40 CRAN - Centre de Recherche en Automatique de Nancy
41 Département de chirurgie
42 Centre Léon Bérard [Lyon]
43 Hôpital Louis Mourier - AP-HP [Colombes]
44 Department of Gynecology and Obstetrics
45 LNC - Lipides - Nutrition - Cancer (U866)
46 Hôpitaux Sud - Hôpital Sainte-Marguerite [CHU - APHM]
47 Service de Biopathologie [CHRU Montpellier]
48 Chirurgie digestive
49 Laboratoire Joliot Curie
50 CRLC Val d'Aurelle-Paul Lamarque
51 Service de Chirurgie Digestive, Cancérologique, Générale, Endocrinienne et Urgences (CHU de Dijon)
52 Laboratoire d'Anatomie Pathologique
53 Department of Radiology
54 Centre René Gauducheau
55 Institut Curie [Paris]
56 UCBL - Université Claude Bernard Lyon 1
57 CIT - (le programme) Cartes d'identité des tumeurs
58 ICM - Institut régional de Cancérologie de Montpellier
59 CRCNA - Centre de Recherche en Cancérologie Nantes-Angers
60 LEM - Laboratoire d'éthique médicale et médecine légale
61 Service de Pathologie
62 CIOH - Centro de Investigaciones Oceanograficas e Hidrograficas
63 IMER - Pôle Information Médicale Evaluation Recherche
64 Service de chirurgie digestive, générale et cancérologique [CHU HEGP]

Purpose: Psammocarcinoma (PK) is a rare disease of unknown origin. We aimed to report the characteristics, management and survival of patients operated on for PK within the French Network for Rare Peritoneal Malignancies (RENAPE) expert centers.Patients and methods: All consecutive cases of PK operated within all 26 RENAPE centers between 1997 and 2018 were retrospectively analyzed.Results: Twenty-five patients were identified. The median age was 53 years [range 17–78]. None of the patients had extra peritoneal metastases at diagnosis. A median of 6 cycles of carboplatin-based systemic chemotherapy was delivered in 52% preoperatively (n = 13) and 56% postoperatively (n = 14); associated with placlitaxel for 12 patients. All patients were operated on. The median PCI was 23 [0–33]. Eighty-four percent had a complete cytoreductive surgery through digestive (n = 7), spleen (n = 3), pancreas (n = 1) resections and/or multiple peritonectomies (n = 11). Five patients (20%) had intraperitoneal chemotherapy. Morbidity (Dindo-Clavien ≥3) was 12%. No postoperative death occurred. After a median follow-up of 42 months (range [2–194]), the median overall (OS) and progression-free (DFS) survival times were respectively 128 months and 31 months. Eighteen patients recurred (72%), mainly in the peritoneum (n = 16). Four of them (22%) were reoperated. The 5 and 10-year DFS rates were both 20.3%. The 5 and 10-year OS rates were 62% and 51.7%, respectively. A complete cytoreductive surgery was associated with a better OS and DFS in a univariate analysis.Conclusion: Complete cytoreductive surgery is the cornerstone of the PK's management as a primary treatment. Recurrence remains common and new adjuvant strategies seem needed.

Mots clés: Intraperitoneal chemotherapy; Psammocarcinoma; Peritoneum; Ovary; Surgery

Domaines: Biologie moléculaire; Bactériologie

Jean-Baptiste Delhorme, Jordan Ohayon, Sébastien Gouy, Catherine Genestie, Léopold Gaichies, et al.. Ovarian and peritoneal psammocarcinoma: Results of a multicenter study on 25 patients. EJSO - European Journal of Surgical Oncology, 2020, 46 (5), pp.862-867. ⟨10.1016/j.ejso.2019.12.005⟩. ⟨hal-02533020⟩