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Article Dans Une Revue Epidemics Année : 2013

Infectivity of GI and GII noroviruses established from oyster related outbreaks

Résumé

Noroviruses (NoVs) are the major cause of acute epidemic gastroenteritis in industrialized countries. Outbreak strains are predominantly genogroup II (GII) NoV, but genogroup I (GI) strains are regularly found in oyster related outbreaks. The prototype Norwalk virus (GI), has been shown to have high infectivity in a human challenge study. Whether other NoVs are equally infectious via natural exposure remains to be established. Human susceptibility to NoV is partly determined by the secretor status (Se+/-). Data from five published oyster related outbreaks were analyzed in a Bayesian framework. Infectivity estimates where high and consistent with NV(GI) infectivity, for both GII and GI strains. The median and CI95 probability of infection and illness, in Se+ subjects, associated with exposure to a mean of one single NoV genome copy were around 0.29[0.015–0.61] for GI and 0.4[0.04–0.61] for GII, and for illness 0.13 [0.007–0.39] for GI and 0.18 [0.017–0.42] for GII. Se- subjects were strongly protected against infection. The high infectivity estimates for Norwalk virus GI and GII, makes NoVs critical target for food safety regulations.

Dates et versions

hal-02646936 , version 1 (29-05-2020)

Identifiants

Citer

Anne Thébault, Peter Teunis, Jacques Le Pendu, Soizick Françoise Le Guyader, Jean-Baptiste Denis. Infectivity of GI and GII noroviruses established from oyster related outbreaks. Epidemics, 2013, 5 (2), pp.98-110. ⟨10.1016/j.epidem.2012.12.004⟩. ⟨hal-02646936⟩
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