STAT3 as a new autophagy regulator

Barbara Jonchère (1, 2) , Audrey Bélanger (1, 2) , Catherine Guette (2, 1) , Benjamin Barré (1, 2) , Olivier Coqueret (2, 1)

1 CRLCC Paul Papin - CRLCC - Centre Paul Papin
2 CRCNA - Centre de Recherche en Cancérologie Nantes-Angers

Signal transducers and activators of transcription 3 (STAT3) proteins are cytoplasmic transcription factors that translocate into the nucleus to induce transcription following growth factor or cytokine stimulation. Besides their normal functions, these proteins play an important role in cancer cells through the abnormal activation of cell cycle progression and the deregulation of survival and senescence pathways. New data obtained from the laboratory of Guido Kroemer identifies STAT3 as a new autophagy regulator. In the cytoplasm, in the absence of conventional phosphorylation on the tyrosine 705 residue, STAT3 interacts with the PKR kinase to inhibit eIF2A phosphorylation and so reduce autophagic pathways. This new and nonconventional function of STAT3 has an important role in normal cells but we suggest that it might also affect cancer cells and the response to chemotherapy treatment.

Mots clés: STAT3; autophagy; cell death; oncogene; senescence

Domaines: Sciences du Vivant [q-bio]

Barbara Jonchère, Audrey Bélanger, Catherine Guette, Benjamin Barré, Olivier Coqueret. STAT3 as a new autophagy regulator. JAK-STAT, 2013, 2 (3), Non spécifié. ⟨10.4161/jkst.24353⟩. ⟨hal-03389742⟩