Radioimmunotherapy for Treatment of Acute Leukemia - Centre de recherche en cancérologie Nantes-Angers Unité Mixte de Recherche 892 Inserm - 6299 CNRS Accéder directement au contenu
Article Dans Une Revue Seminars in Nuclear Medicine Année : 2016

Radioimmunotherapy for Treatment of Acute Leukemia

Patrice Chevallier

Résumé

Acute leukemias are characterized by accumulation of immature cells (blasts) and reduced production of healthy hematopoietic elements. According to the lineage origin, two major leukemias can be distinguished: acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL). Although the survival rate for pediatric ALL is close to 90%, half of the young adults with AML or ALL and approximately 90% of older patients with AML or ALL still die of their disease, raising the need for innovative therapeutic approaches. As almost all leukemic blasts express specific surface antigens, targeted immunotherapy appears to be particularly promising. However, published results of immunotherapy alone are generally modest. Radioimmuno-therapy (RIT) brings additional therapeutic mechanisms using radiolabeled monoclonal antibodies (mAbs) directed to tumor antigens, thus adding radiobiological cytotoxicity to immunologic cytotoxicity. Because of the high radiosensitivity of tumor cells and the diffuse widespread nature of the disease, making it rapidly accessible to circulating radiolabeled mAbs, acute leukemias represent relevant indications for RIT. With the development of recombinant and humanized mAbs, innovative radionuclides, and more efficient radiolabeling and pretargeting techniques, RIT has significantly improved over the last 10 years. Different approaches of α and β RIT targeting CD22, CD33, CD45, or CD66 antigens have already been evaluated or are currently being developed in the treatment of acute leukemia. This review summarizes the preclinical and clinical studies demonstrating the potential of RIT in treatment of AML and ALL. Semin Nucl Med 46:135-146 C

Domaines

Cancer
Fichier sous embargo
Fichier sous embargo
Date de visibilité indéterminée
Loading...

Dates et versions

inserm-01280232 , version 1 (29-02-2016)

Identifiants

Citer

Caroline Bodet-Milin, Françoise Kraeber-Bodéré, Thomas Eugène, François Guérard, Joëlle Gaschet, et al.. Radioimmunotherapy for Treatment of Acute Leukemia. Seminars in Nuclear Medicine, 2016, 46, pp.135-146. ⟨10.1053/j.semnuclmed.2015.10.007⟩. ⟨inserm-01280232⟩
56 Consultations
2 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More