The phosphorylation of Metaxin 1 controls Bak activation during TNFα induced cell death - Centre de recherche en cancérologie Nantes-Angers Unité Mixte de Recherche 892 Inserm - 6299 CNRS Accéder directement au contenu
Article Dans Une Revue Cellular Signalling Année : 2016

The phosphorylation of Metaxin 1 controls Bak activation during TNFα induced cell death

Résumé

The proapoptotic protein Bak is implicated in the execution phase of apoptosis, a cell death program. Bak is essentially mitochondrial and during early steps of apoptosis undergoes conformational changes that lead to its full membrane integration in mitochondria and the subsequent liberation of pro-apoptotic mitochondrial proteins. Little is known about the partners and mechanisms implicated in the activation of Bak. We have recently shown that Bak is incorporated into a Voltage dependent anionic channel of type 2 (VDAC2)/Metaxin 1(Mtx1)/Metaxin 2 (Mtx2) multi-protein complex in both resting and dying cells. Here, we show that, after the induction of apoptosis, Bak switches from its association with Mtx2 and VDAC2 to a closer association with Mtx1. This change of partners is under the control of a tyrosine phosphorylation of Mtx1 by c-Abl.

Domaines

Cancer
Fichier principal
Vignette du fichier
CellSignalEqu09.pdf (1.26 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

inserm-01398677 , version 1 (17-11-2016)

Identifiants

Citer

Elise Petit, Pierre-François Cartron, Lisa Oliver, François M Vallette. The phosphorylation of Metaxin 1 controls Bak activation during TNFα induced cell death. Cellular Signalling, 2016, 30, pp.171-178. ⟨10.1016/j.cellsig.2016.11.008⟩. ⟨inserm-01398677⟩
278 Consultations
570 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More