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Reconstruction tomographique 3D complète par modélisation Monte Carlo de la matrice système en TEP pré-clinique à l’iode 124

Moreau Matthieu 1, 2 
2 AMaROC - Animaux modèles pour la recherche en oncologie comparée
ONIRIS - École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique
Abstract : Immuno-PET imaging can be used to assess the pharmacokinetic in radioimmunotherapy. When using iodine- 124, PET quantitative imaging is limited by physics-based degrading factors within the detection system and the object, such as the long positron range in water and the complex spectrum of gamma photons. The objective of this thesis was to develop a fully 3D tomographic reconstruction method (S(MC)2PET) using Monte Carlo simulations for estimating the system matrix, in the context of preclinical imaging with iodine-124. The Monte Carlo simulation platform GATE was used for that respect. Several complexities of system matrices were calculated, with at least a model of the PET system response function. Physics processes in the object was either neglected or taken into account using a precise or a simplified object description. The impact of modelling refinement and statistical variance related to the system matrix elements was evaluated on final reconstructed images. These studies showed that a high level of complexity did not always improve qualitative and quantitative results, owing to the high-variance of the associated system matrices.
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https://hal.archives-ouvertes.fr/tel-01122928
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Submitted on : Wednesday, March 4, 2015 - 7:19:59 PM
Last modification on : Saturday, April 9, 2022 - 4:34:06 PM
Long-term archiving on: : Friday, June 5, 2015 - 11:25:16 AM

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Moreau Matthieu. Reconstruction tomographique 3D complète par modélisation Monte Carlo de la matrice système en TEP pré-clinique à l’iode 124. Physique [physics]. Faculté de Médecine et des Techniques Médicales - Nantes, 2014. Français. ⟨tel-01122928⟩

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