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Etude de l’épidémiologie moléculaire et de l’écologie d’Acinetobacter spp au Liban

Abstract : Acinetobacter spp are opportunistic bacteria widely involved in nosocomial infections. The aim of this work was to study the epidemiology and the ecology of these bacteria in Lebanon. First, we have analyzed 119 clinical strains of A.baumannii. 76.5% of them were resistant to carbapenems and the production of OXA-23 was the main mechanism. Multi-locus sequence typing revealed the predominance of international clone II. Pulsed field gel electrophoresis showed that 72.6% of strains belonging to ST2 were classified in the same cluster which appeared to be predominant in Beirut and Tripoli. On the other hands, Acinetobacter reservoirs were investigated on 2361 samples collected in Lebanon. A total number of 171 strains have been isolated in the environment, food, humans and animals. The majority of these strains was identified as non baumannii Acinetobacter and was susceptible to antibiotics. Besides, typing of A.baumannii revealed the presence of 14 STs including 10 new ones. Finally, we have described a novel species called “Acinetobacter lebanonensis” by conducting a taxonomic study on several strains isolated in Lebanon and other countries. Although the data may be limited, this work has shown the endemic situation of carbapenem resistant A.baumannii circulating in the Lebanese hospitals while the extra hospital ones were different. However, further studies are needed to elucidate the origin of these emerging multidrug resistant strains.
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Submitted on : Monday, October 2, 2017 - 1:17:40 AM
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Ahmad Al Atrouni. Etude de l’épidémiologie moléculaire et de l’écologie d’Acinetobacter spp au Liban. Médecine humaine et pathologie. Université d'Angers; Université libannaise de Beyrouth, 2017. Français. ⟨NNT : 2017ANGE0004⟩. ⟨tel-01599268⟩

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