Structure, biosynthesis, and properties of kurstakins, nonribosomal lipopeptides from Bacillus spp.

Max Béchet (1) , Thibault Caradec (1) , Walaa Hussein (1) , Ahmed Abderrahmani (2) , Marlène Chollet (1) , Valérie Leclère (1) , Thomas Dubois (3, 4) , Didier Lereclus (3, 4) , Maude Pupin (5, 6) , Philippe Jacques (1)

1 PROBIOGEM - Laboratoire des Procédés Biologiques Génie Enzymatique et Microbien
2 Laboratoire de Biologie Cellulaire et Moléculaire
3 GME - Génétique Microbienne et Environnement
4 MICALIS - MICrobiologie de l'ALImentation au Service de la Santé
5 LIFL - Laboratoire d'Informatique Fondamentale de Lille
6 BONSAI - Bioinformatics and Sequence Analysis

A new family of lipopeptides produced by Bacillus thuringiensis, the kurstakins, was discovered in 2000 and considered as a biomarker of this species. Kurstakins are lipoheptapeptides displaying antifungal activities against Stachybotrys charatum. Recently, the biosynthesis mechanism, the regulation of this biosynthesis and the potential new properties of kurstakins were described in the literature. In addition, kurstakins were also detected in other species belonging to Bacillus genus such as Bacillus cereus. This mini-review gathers all the information about these promising bioactive molecules.

Mots clés: Kurstakins; Lipopeptides; Bacillus cereus; Bacillus thuringiensis; nonribosomal synthesis; NRPS; Spreading

Domaines: Bactériologie; Bio-Informatique, Biologie Systémique [q-bio.QM]; Bio-informatique [q-bio.QM]

Max Béchet, Thibault Caradec, Walaa Hussein, Ahmed Abderrahmani, Marlène Chollet, et al.. Structure, biosynthesis, and properties of kurstakins, nonribosomal lipopeptides from Bacillus spp.. Applied Microbiology and Biotechnology, 2012, 95 (3), pp.593-600. ⟨10.1007/s00253-012-4181-2⟩. ⟨hal-00749819⟩