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Article Dans Une Revue Trends in Parasitology Année : 2020

Skin Interface, a Key Player for Borrelia Multiplication and Persistence in Lyme Borreliosis

Résumé

The skin plays a key role in vector-borne diseases because it is the site where the arthropod coinoculates pathogens and its saliva. Lyme borreliosis, particularly well investigated in this context, is a multisystemic infectious disease caused by Borrelia burgdorferi sensu lato and transmitted by the hard tick Ixodes. Numerous in vitro studies were conducted to better understand the role of specific skin cells and tick saliva in host defense, vector feeding, and pathogen transmission. The skin was also evidenced in various animal models as the site of bacterial multiplication and persistence. We present the achievements in this field as well as the gaps that impede comprehensive knowledge of the disease pathophysiology and the development of efficient diagnostic tools and vaccines in humans. Copyright © 2020 Elsevier Ltd. All rights reserved.

Domaines

Chimie

Dates et versions

hal-02492974 , version 1 (27-02-2020)

Identifiants

Citer

Quentin Bernard, Antoine Grillon, Cédric Lenormand, Laurence Ehret-Sabatier, Nathalie Boulanger. Skin Interface, a Key Player for Borrelia Multiplication and Persistence in Lyme Borreliosis. Trends in Parasitology, 2020, 36 (3), pp.304-314. ⟨10.1016/j.pt.2019.12.017⟩. ⟨hal-02492974⟩
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