BIODISTRIBUTION OF siRNA DELIVERED WITH CHITOSAN-DECORATED POLY(ISOBUTYLCYANOACRYLATE) NANOPARTICLES

A L Ramon (1, 2) , J R Bertrand (2) , C Zandanel (1) , Christine Vauthier (1) , C Malvy (2)

1 IGPS - Institut Galien Paris-Saclay
2 UMR 8203 - Vectorologie et thérapeutiques anti-cancéreuses [Villejuif]

This work explored biodistribution of the siRNA and that of the nanoparticle carrier after an intravenous administration to mice xenografted with a model tumor of Ewing sarcoma. The chitosan-decorated poly(isobutylcyanoacrylate) nanoparticles considered in this work could deliver the siRNA in the tumor in agreement with their own distribution in the tumor xenografted in mice. The addition of a targeting ligand to the nanoparticles increased further the accumulation of the delivery platform in the tumor.

Mots clés: siRNA; biodistribution; Ewing Sarcoma model; poly(alkylcyanoacrylate) nanoparticles; mice

Domaines: Pharmacie galénique; Biomatériaux

A L Ramon, J R Bertrand, C Zandanel, Christine Vauthier, C Malvy. BIODISTRIBUTION OF siRNA DELIVERED WITH CHITOSAN-DECORATED POLY(ISOBUTYLCYANOACRYLATE) NANOPARTICLES. : Abstract book of the 16th International Symposium on Recent Advances in Drug Delivery Systems. Salt Lake City, UT, USA,, Feb 2013, Salt Lake City, UT, United States. pp.Abstract #66. ⟨hal-03194771⟩