Biological Fate of Fe3O4 Core-Shell Mesoporous Silica Nanoparticles Depending on Particle Surface Chemistry

Estelle Rascol (1) , Morgane Daurat (2, 3) , Afitz da Silva (3, 2) , Marie Maynadier (3) , Christophe Dorandeu (1) , Clarence Charnay (1) , Marcel Garcia (2) , Josephine Lai-Kee-Him (4) , Patrick Bron (4) , Melanie Auffan (5) , Wei Liu (5) , Bernard Angeletti (5) , Jean-Marie Devoisselle (1) , Yannick Guari (1) , Magali Gary-Bobo (2) , Joel Chopineau (1, 6)

1 ICGM - Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier
2 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]
3 NMS - NanoMedSyn
4 CBS - Centre de Biochimie Structurale [Montpellier]
5 CEREGE - Centre européen de recherche et d'enseignement des géosciences de l'environnement
6 UNIMES - Université de Nîmes

The biological fate of nanoparticles (NPs) for biomedical applications is highly dependent of their size and charge, their aggregation state and their surface chemistry. The chemical composition of the NPs surface influences their stability in biological fluids, their interaction with proteins, and their attraction to the cell membranes. In this work, core-shell magnetic mesoporous silica nanoparticles (Fe3O4@ MSN), that are considered as potential theranostic candidates, are coated with polyethylene glycol (PEG) or 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) lipid bilayer. Their biological fate is studied in comparison to the native NPs. The physicochemical properties of these three types of NPs and their suspension behavior in different media are investigated. The attraction to a membrane model is also evaluated using a supported lipid bilayer. The surface composition of NPs strongly influences their dispersion in biological fluids mimics, protein binding and their interaction with cell membrane. While none of these types of NPs is found to be toxic on mice four days after intravenous injection of a dose of 40 mg kg(-1) of NPs, their surface coating nature influences the in vivo biodistribution. Importantly, NP coated with DMPC exhibit a strong accumulation in liver and a very low accumulation in lung in comparison with nude or PEG ones.

Mots clés: biodistribution; safety; nanoparticles; surface coating; cell-membrane interactions

Domaines: Sciences de la Terre; Biotechnologie

Estelle Rascol, Morgane Daurat, Afitz da Silva, Marie Maynadier, Christophe Dorandeu, et al.. Biological Fate of Fe3O4 Core-Shell Mesoporous Silica Nanoparticles Depending on Particle Surface Chemistry. Nanomaterials, 2017, 7 (7), ⟨10.3390/nano7070162⟩. ⟨hal-01765587⟩