Time course of asymptomatic interstitial pulmonary oedema at high altitude.

Pierre Bouzat (1) , Guillaume Walther (2) , Thomas Rupp (3) , Gregory Doucende (4) , Jean-François Payen (5) , Patrick Levy (3) , Samuel Verges (3)

1 ANTE-INSERM U836, équipe 5 - Neuro-imagerie fonctionnelle et métabolique
2 LaPEC - EA4278 Laboratoire de Pharm-Ecologie Cardiovasculaire
3 HP2 - Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire
4 LEPSA - Laboratoire Européen Performance Santé Altitude
5 GIN - Grenoble Institut des Neurosciences

The time course of asymptomatic pulmonary oedema during high-altitude exposure and its potential relationship with changes in cardiac function remain to clarify. Eleven volunteers were rapidly exposed to 4350m during a 4-day period. Each subject received clinical examination and thoracic ultrasonography to assess ultrasound lung comets (USLC) on day 1, 2 and 3 after arrival. Echocardiography was performed on day 2 and 4 at 4350m. All subjects had a significant increase in the number of USLC on day 1 (n=8±3), day 2 (n=7±4) and day 3 (n=3±2) compared to sea level (n=1±1) (P<0.01). Although left ventricle diastolic function and systolic tricuspid regurgitation gradient were significantly different at altitude compared to sea level, they did not correlate with the number of USLC (P>0.05). Asymptomatic pulmonary oedema seems to be transiently present in fast-ascending recreational climbers. The lack of correlation between the number of USLC and indices of cardiac changes suggest that non-cardiogenic mechanisms may underlie this transient increase in lung water.

Domaines: Physiologie [q-bio.TO]; Pneumologie et système respiratoire

Pierre Bouzat, Guillaume Walther, Thomas Rupp, Gregory Doucende, Jean-François Payen, et al.. Time course of asymptomatic interstitial pulmonary oedema at high altitude.. Respiratory Physiology & Neurobiology, 2012, 186 (1), pp.16-21. ⟨10.1016/j.resp.2012.12.009⟩. ⟨hal-00800441⟩