Radiation Therapy Using Synchrotron Radiation: Preclinical Studies Toward Clinical Trials

Jean-François Adam (1) , Jacques Balosso (1) , Laure Bobyk (1) , Anne-Marie Charvet (1) , Pierre Deman (1) , Magali Edouard (2, 3) , Hélène Elleaume (2, 4) , François Estève (2, 3) , Jean-François Le Bas (1) , Julia Rousseau (1) , Raphaël Serduc (1) , Mathias Vautrin (1) , Tanguy Chabrol (5) , Antoine Depaulis (5) , Benoit Pouyatos (5) , Jose Baruchel (4) , Paul Berkvens (3) , Gilles Berruyer (3) , Audrey Bouchet (5) , Elke Bräuer-Krisch (3) , Alberto Bravin (3) , Thierry Brochard (3) , Dominique Dallery (3) , Géraldine Le Duc (3) , Christian Nemoz (3) , Immaculada Martinez-Rovira (3, 6) , Yolanda Prezado (3) , Michel Renier (3) , Herwig Requardt (3) , Mehdi Benkebil (7) , Jean Laissue (8)

1 INSERM U836, équipe 6, Rayonnement synchrotron et recherche médicale
2 GIN - Grenoble Institut des Neurosciences
3 ID17 - Biomedical Beamline
4 ID19 - High-resolution Diffraction Topography Beamline
5 INSERM U836, équipe 9, Dynamique des réseaux synchrones épileptiques
6 Institut de techniques énergétiques
7 DOSIsoft
8 Oncology - Pathology - Anatomy

After decades of intensive research, high-grade gliomas are still resistant to therapies, including surgery, chemotherapy, and radiotherapy or a combination thereof. The most important advance in the treatment of these tumors has been the introduction of a new chemotherapy drug called temozolomide, in combination with external beam photon irradiation [1]. One of the goals of the association of the CHU/UJF/ INSERM and ESRF teams has been to develop research on synchrotron radiotherapy up to clinics.

Domaines: Médecine nucléaire; Cancer

Jean-François Adam, Jacques Balosso, Laure Bobyk, Anne-Marie Charvet, Pierre Deman, et al.. Radiation Therapy Using Synchrotron Radiation: Preclinical Studies Toward Clinical Trials. Synchrotron Radiation News, 2011, 24 (2), pp.8-12. ⟨10.1080/08940886.2011.567160⟩. ⟨inserm-00676923⟩