Embedding of biological regulatory networks and property preservation

Abstract : In the course of understanding biological regulatory networks (BRN), scientists usually start by studying small BRNs that they believe to be of particular importance to represent a biological function, and then, embed them in a larger network. Such a reduction can lead to neglect relevant regulations and to study a network whose properties can be very different from the properties of this network viewed as a part of the whole. In this paper we study, from a logical point of view, on which conditions concerning both networks, properties can be inherited by BRNs from sub-BRNs.We give some conditions on the nature of the network embeddings ensuring that dynamic properties on the embedded sub-BRNs are preserved at the level of the whole BRN.
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Mbarka Mabrouki, Marc Aiguier, Jean-Paul Comet, Pascale Le Gall, Adrien Richard. Embedding of biological regulatory networks and property preservation. Mathematics in Computer Science, Springer, 2011, 5 (1), pp.263-288. ⟨hal-00782867⟩

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