Skip to Main content Skip to Navigation
Journal articles

A mechanical model to investigate the role of the nucleus during confined cell migration

Résumé : Cell migration in confinement plays a fundamental role in biological processes such as embryogenesis, immune response and tumorogenesis. Specifically, tumor cells continuously adapt their migratory behaviour to their environment. Therefore, it has become timely and essential for diagnostic purposes to quantitatively evaluate the cell deformability in confinement. Here, we propose a two-dimensional mechanical model to simulate the migration of a HeLa cell through a micro- channel. We will evaluate both the invasiveness of the cell and the mechanical forces exerted by the cell according to the surrounding microstructure.
Document type :
Journal articles
Complete list of metadatas

Cited literature [10 references]  Display  Hide  Download

https://hal-ecp.archives-ouvertes.fr/hal-01338317
Contributor : Nathalie Langlet <>
Submitted on : Monday, May 11, 2020 - 9:20:30 AM
Last modification on : Thursday, July 16, 2020 - 9:24:58 AM

File

IBHGC_CMBBE_2015_ALLENA.pdf
Files produced by the author(s)

Identifiers

Citation

Rachele Allena, H. Thiam, M. Piel, Denis Aubry. A mechanical model to investigate the role of the nucleus during confined cell migration. Computer Methods in Biomechanics and Biomedical Engineering, 2015, 18, pp.1868-1869. ⟨10.1080/10255842.2015.1070576⟩. ⟨hal-01338317⟩

Share

Metrics

Record views

331

Files downloads

69