Chk1 and Chk2 kinases in checkpoint control and cancer, Cancer Cell, vol.3, issue.5, pp.421-429, 2003. ,
DOI : 10.1016/S1535-6108(03)00110-7
Cellular Responses to DNA Damage: One Signal, Multiple Choices, Annual Review of Genetics, vol.40, issue.1, pp.187-208, 2006. ,
DOI : 10.1146/annurev.genet.40.110405.090428
Aneuploidy and cancer, Nature, vol.101, issue.7015, pp.338-341, 2004. ,
DOI : 10.1038/nature03099
Live or let die: the cell's response to p53, Nature Reviews Cancer, vol.2, issue.8, pp.594-604, 2002. ,
DOI : 10.1038/nrc864
Rapid Destruction of Human Cdc25A in Response to DNA Damage, Science, vol.288, issue.5470, pp.1425-1429, 2000. ,
DOI : 10.1126/science.288.5470.1425
Mitotic and G2 Checkpoint Control: Regulation of 14-3-3 Protein Binding by Phosphorylation of Cdc25C on Serine-216, Science, vol.277, issue.5331, pp.1501-1505, 1997. ,
DOI : 10.1126/science.277.5331.1501
Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25, Science, vol.277, issue.5331, pp.1497-1501, 1997. ,
DOI : 10.1126/science.277.5331.1497
The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase??initiation, Genes & Development, vol.12, issue.12, pp.1871-1883, 1998. ,
DOI : 10.1101/gad.12.12.1871
Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation, Nature Genetics, vol.20, issue.2, pp.189-193, 1998. ,
DOI : 10.1038/2496
Aurora kinases, aneuploidy and cancer, a coincidence or a real link?, Trends in Cell Biology, vol.15, issue.5, pp.241-250, 2005. ,
DOI : 10.1016/j.tcb.2005.03.004
URL : https://hal.archives-ouvertes.fr/inserm-00966568
Aurora kinases link chromosome segregation and cell division to cancer susceptibility, Current Opinion in Genetics & Development, vol.14, issue.1, pp.29-36, 2004. ,
DOI : 10.1016/j.gde.2003.11.006
Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells, The EMBO Journal, vol.21, issue.4, pp.483-492, 2002. ,
DOI : 10.1093/emboj/21.4.483
Inhibition of Aurora A in response to DNA damage, Oncogene, vol.20, pp.338-348, 2006. ,
DOI : 10.1038/sj.onc.1209056
URL : https://hal.archives-ouvertes.fr/inserm-00966637
Repair of and checkpoint response to topoisomerase I-mediated DNA damage, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.532, issue.1-2, pp.173-203, 2003. ,
DOI : 10.1016/j.mrfmmm.2003.08.016
Transcriptional Regulation by a DNA-associated Form of Cyclin D1, Molecular Biology of the Cell, vol.16, issue.4, pp.1850-1858, 1819. ,
DOI : 10.1091/mbc.E04-08-0654
The STAT3 Transcription Factor Is a Target for the Myc and Riboblastoma Proteins on the Cdc25A Promoter, Journal of Biological Chemistry, vol.280, issue.16, pp.15673-15681, 2005. ,
DOI : 10.1074/jbc.M413203200
RETRACTED: The Skp2 Promoter Integrates Signaling through the NF-??B, p53, and Akt/GSK3?? Pathways to Regulate Autophagy and Apoptosis, Molecular Cell, vol.38, issue.4, pp.524-538, 2010. ,
DOI : 10.1016/j.molcel.2010.03.018
The EGFR-STAT3 Oncogenic Pathway Up-regulates the Eme1 Endonuclease to Reduce DNA Damage after Topoisomerase I Inhibition, Cancer Research, vol.68, issue.3, pp.815-825, 2008. ,
DOI : 10.1158/0008-5472.CAN-07-5115
The Cell Cycle Inhibitor p21waf1 Binds to the myc and cdc25A Promoters upon DNA Damage and Induces Transcriptional Repression, Journal of Biological Chemistry, vol.281, issue.46, pp.34742-34750, 2006. ,
DOI : 10.1074/jbc.M602492200
Src Inhibits Adriamycin-Induced Senescence and G2 Checkpoint Arrest by Blocking the Induction of p21waf1, Cancer Research, vol.65, issue.19, pp.8927-8935, 2005. ,
DOI : 10.1158/0008-5472.CAN-05-0461
http://www.molecular-cancer.com/content, Molecular Cancer Bromberg, J. J. Clin. Invest, vol.99205, issue.109, pp.205-1139, 2002. ,
The STATs of cancer ??? new molecular targets come of age, Nature Reviews Cancer, vol.99, issue.2, pp.97-105, 2004. ,
DOI : 10.1038/nrc1275
What does Stat3 do?, Journal of Clinical Investigation, vol.109, issue.9, pp.1143-1148, 2002. ,
DOI : 10.1172/JCI0215650
Stat3 as an Oncogene, Cell, vol.98, issue.3, pp.295-303, 1999. ,
DOI : 10.1016/S0092-8674(00)81959-5
URL : http://doi.org/10.1016/s0092-8674(00)81959-5
Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation, Cell, vol.82, issue.2, pp.241-250, 1995. ,
DOI : 10.1016/0092-8674(95)90311-9
Functional Interaction of STAT3 Transcription Factor with the Coactivator NcoA/SRC1a, Journal of Biological Chemistry, vol.277, issue.10, pp.8004-8011, 2002. ,
DOI : 10.1074/jbc.M111486200
Implication of BRG1 and cdk9 in the STAT3-mediated activation of the p21waf1 gene, Oncogene, vol.23, issue.44, pp.7391-7398, 2004. ,
DOI : 10.1038/sj.onc.1207972
Stat Protein Transactivation Domains Recruit p300/CBP through Widely Divergent Sequences, Journal of Biological Chemistry, vol.274, issue.36, pp.25343-25349, 1999. ,
DOI : 10.1074/jbc.274.36.25343
Synergistic Signaling in Fetal Brain by STAT3-Smad1 Complex Bridged by p300, Science, vol.284, issue.5413, pp.479-482, 1999. ,
DOI : 10.1126/science.284.5413.479
Activation of Signal Transducer and Activator of Transcription 3 through a Phosphomimetic Serine 727 Promotes Prostate Tumorigenesis Independent of Tyrosine 705 Phosphorylation, Cancer Research, vol.68, issue.19, pp.7736-7741, 2008. ,
DOI : 10.1158/0008-5472.CAN-08-1125
Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NF??B, Genes & Development, vol.21, issue.11, pp.1396-1408, 2007. ,
DOI : 10.1101/gad.1553707
Persistently Activated Stat3 Maintains Constitutive NF-??B Activity in Tumors, Cancer Cell, vol.15, issue.4, pp.283-293, 2009. ,
DOI : 10.1016/j.ccr.2009.02.015
The STAT3 oncogene as a predictive marker of drug resistance, Trends in Molecular Medicine, vol.13, issue.1, pp.4-11, 2007. ,
DOI : 10.1016/j.molmed.2006.11.001
Signal Transducer and Activator of Transcription 3 Is a Key Regulator of Keratinocyte Survival and Proliferation following UV Irradiation, Cancer Research, vol.65, issue.13, pp.5720-5729, 2005. ,
DOI : 10.1158/0008-5472.CAN-04-4359
Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1, Proceedings of the National Academy of Sciences, vol.98, issue.4, pp.1543-1548, 2001. ,
DOI : 10.1073/pnas.98.4.1543
Role of Stat3 in Regulating p53 Expression and Function, Molecular and Cellular Biology, vol.25, issue.17, pp.7432-7440, 2005. ,
DOI : 10.1128/MCB.25.17.7432-7440.2005
Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells, Immunity, vol.10, issue.1, pp.105-115, 1999. ,
DOI : 10.1016/S1074-7613(00)80011-4
Signal Transducers and Activators of Transcription 3 Pathway Activation in Drug-Resistant Ovarian Cancer, Clinical Cancer Research, vol.12, issue.17, pp.5055-5063, 2006. ,
DOI : 10.1158/1078-0432.CCR-06-0861
Activation of Stat3 in Primary Tumors from High-Risk Breast Cancer Patients Is Associated with Elevated Levels of Activated Src and Survivin Expression, Clinical Cancer Research, vol.12, issue.1, pp.20-28, 2006. ,
DOI : 10.1158/1078-0432.CCR-04-1749
Persistent Activation of Stat3 Signaling Induces Survivin Gene Expression and Confers Resistance to Apoptosis in Human Breast Cancer Cells, Clinical Cancer Research, vol.12, issue.1, pp.11-19, 2006. ,
DOI : 10.1158/1078-0432.CCR-04-1752
Src Inhibits Adriamycin-Induced Senescence and G2 Checkpoint Arrest by Blocking the Induction of p21waf1, Cancer Research, vol.65, issue.19, pp.8927-8935, 2005. ,
DOI : 10.1158/0008-5472.CAN-05-0461
The EGFR-STAT3 Oncogenic Pathway Up-regulates the Eme1 Endonuclease to Reduce DNA Damage after Topoisomerase I Inhibition, Cancer Research, vol.68, issue.3, pp.815-825, 2008. ,
DOI : 10.1158/0008-5472.CAN-07-5115
A decade of CDK5, Nature Reviews Molecular Cell Biology, vol.4, issue.10, pp.749-759, 2001. ,
DOI : 10.1038/35096019
Cdk5-Mediated Inhibition of the Protective Effects of Transcription Factor MEF2 in Neurotoxicity-Induced Apoptosis, Neuron, vol.38, issue.1, pp.33-46, 2003. ,
DOI : 10.1016/S0896-6273(03)00191-0
Cyclin-dependent kinase-5 prevents neuronal apoptosis through ERK-mediated upregulation of Bcl-2, Cell Death and Differentiation, vol.13, issue.7, pp.1203-1212, 2006. ,
DOI : 10.1126/science.286.5448.2358
The Cell Cycle Inhibitor p21waf1 Binds to the myc and cdc25A Promoters upon DNA Damage and Induces Transcriptional Repression, Journal of Biological Chemistry, vol.281, issue.46, pp.34742-34750, 2006. ,
DOI : 10.1074/jbc.M602492200
Cyclin-dependent Kinase Inhibitors Uncouple Cell Cycle Progression from Mitochondrial Apoptotic Functions in DNA-damaged Cancer Cells, Journal of Biological Chemistry, vol.280, issue.36, pp.32018-32025, 2005. ,
DOI : 10.1074/jbc.M504689200
Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death, Nature Cell Biology, vol.20, issue.2, pp.211-218, 2009. ,
DOI : 10.1016/0092-8674(93)90500-P
Cellular Senescence Requires CDK5 Repression of Rac1 Activity, Molecular and Cellular Biology, vol.24, issue.7, pp.2808-2819, 2004. ,
DOI : 10.1128/MCB.24.7.2808-2819.2004
Increased Ezrin Expression and Activation by CDK5 Coincident with Acquisition of the Senescent Phenotype, Molecular Cell, vol.11, issue.5, pp.1163-1176, 2003. ,
DOI : 10.1016/S1097-2765(03)00135-7
Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity, Proceedings of the National Academy of Sciences, vol.101, issue.17, pp.6728-6733, 2004. ,
DOI : 10.1073/pnas.0307606100
Cyclin D1 Is Transcriptionally Regulated by and Required for Transformation by Activated Signal Transducer and Activator of Transcription 3, Cancer Research, vol.66, issue.5, pp.2544-2552, 2006. ,
DOI : 10.1158/0008-5472.CAN-05-2203
Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway, Cancer Cell, vol.7, issue.6, pp.575-589, 2005. ,
DOI : 10.1016/j.ccr.2005.05.007
Gene, The Journal of Experimental Medicine, vol.16, issue.1, pp.63-73, 1999. ,
DOI : 10.1016/S1074-7613(00)80445-8
Opposite Regulation of Myc and p21waf1 Transcription by STAT3 Proteins, Journal of Biological Chemistry, vol.278, issue.5, pp.2990-2996, 2003. ,
DOI : 10.1074/jbc.M210422200
The STAT3 Transcription Factor Is a Target for the Myc and Riboblastoma Proteins on the Cdc25A Promoter, Journal of Biological Chemistry, vol.280, issue.16, pp.15673-15681, 2005. ,
DOI : 10.1074/jbc.M413203200
Disruption of Murine Mus81 Increases Genomic Instability and DNA Damage Sensitivity but Does Not Promote Tumorigenesis, Molecular and Cellular Biology, vol.25, issue.17, pp.7569-7579, 2005. ,
DOI : 10.1128/MCB.25.17.7569-7579.2005
Exploring the roles of Mus81-Eme1/Mms4 at perturbed replication forks, DNA Repair, vol.6, issue.7, pp.1004-1017, 2007. ,
DOI : 10.1016/j.dnarep.2007.02.019
Repair of and checkpoint response to topoisomerase I-mediated DNA damage, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.532, issue.1-2, pp.173-203, 2003. ,
DOI : 10.1016/j.mrfmmm.2003.08.016
How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene, The EMBO Journal, vol.136, issue.15, pp.4111-4122, 2000. ,
DOI : 10.1093/emboj/19.15.4111
STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage, Journal of Cell Science, vol.118, issue.8, pp.1629-1639, 2005. ,
DOI : 10.1242/jcs.01728
STAT1: A Modulator of Chemotherapy-induced Apoptosis, Cancer Research, vol.64, issue.22, pp.8357-8364, 2004. ,
DOI : 10.1158/0008-5472.CAN-04-1864
BCR/ABL Regulates Mammalian RecA Homologs, Resulting in Drug Resistance, Molecular Cell, vol.8, issue.4, pp.795-806, 2001. ,
DOI : 10.1016/S1097-2765(01)00357-4
Fusion Tyrosine Kinases Induce Drug Resistance by Stimulation of Homology-Dependent Recombination Repair, Prolongation of G2/M Phase, and Protection from Apoptosis, Molecular and Cellular Biology, vol.22, issue.12, pp.4189-4201, 2002. ,
DOI : 10.1128/MCB.22.12.4189-4201.2002
DNA Replication Stalling Attenuates Tyrosine Kinase Signaling to Suppress S Phase Progression, Cancer Cell, vol.14, issue.2, pp.166-179, 2008. ,
DOI : 10.1016/j.ccr.2008.06.003
c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function, Molecular Cell, vol.9, issue.5, pp.1031-1044, 2002. ,
DOI : 10.1016/S1097-2765(02)00520-8
URL : http://doi.org/10.1016/s1097-2765(02)00520-8
Cisplatin Mimics ARF Tumor Suppressor Regulation of RelA (p65) Nuclear Factor-??B Transactivation, Cancer Research, vol.66, issue.2, pp.929-935, 2006. ,
DOI : 10.1158/0008-5472.CAN-05-2234
Cdk5 Regulates STAT3 Activation and Cell Proliferation in Medullary Thyroid Carcinoma Cells, Journal of Biological Chemistry, vol.282, issue.5, pp.2776-2784, 2007. ,
DOI : 10.1074/jbc.M607234200
Interleukin-6 dependent induction of the cyclin dependent kinase inhibitor p21WAF1/CIP1 is lost during progression of human malignant melanoma, Oncogene, vol.18, issue.4, pp.1023-1032, 1999. ,
DOI : 10.1038/sj.onc.1202382
Transcriptional Regulation by a DNA-associated Form of Cyclin D1, Molecular Biology of the Cell, vol.16, issue.4, pp.1850-1858, 2005. ,
DOI : 10.1091/mbc.E04-08-0654
Cross-Linking of Signal Transducer and Activator of Transcription 3--A Molecular Marker for the Photodynamic Reaction in Cells and Tumors, Clinical Cancer Research, vol.13, issue.11, pp.3156-3163, 2007. ,
DOI : 10.1158/1078-0432.CCR-06-2950
Targeting Signal Transducer and Activator of Transcription Signaling Pathway in Leukemias, Journal of Clinical Oncology, vol.27, issue.26, pp.4422-4432, 2009. ,
DOI : 10.1200/JCO.2008.21.3264