D. Marzo and V. , Formation and inactivation of endogenous cannabinoid anandamide in central neurons, Nature, vol.372, issue.6507, pp.686-91, 1994.
DOI : 10.1038/372686a0

W. A. Devane, Isolation and structure of a brain constituent that binds to the cannabinoid receptor, Science, vol.258, issue.5090, pp.258-1946, 1992.
DOI : 10.1126/science.1470919

R. Mechoulam, Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors, Biochemical Pharmacology, vol.50, issue.1, pp.83-90, 1995.
DOI : 10.1016/0006-2952(95)00109-D

T. Sugiura, 2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain, Biochemical and Biophysical Research Communications, vol.215, issue.1, pp.89-97, 1995.
DOI : 10.1006/bbrc.1995.2437

L. A. Matsuda, Structure of a cannabinoid receptor and functional expression of the cloned cDNA, Nature, vol.346, issue.6284, pp.561-565, 1990.
DOI : 10.1038/346561a0

S. Munro, K. L. Thomas, and M. Abu-shaar, Molecular characterization of a peripheral receptor for cannabinoids, Nature, vol.365, issue.6441, pp.365-61, 1993.
DOI : 10.1038/365061a0

T. F. Freund, I. Katona, and D. Piomelli, Role of Endogenous Cannabinoids in Synaptic Signaling, Physiological Reviews, vol.83, issue.3, pp.1017-66, 2003.
DOI : 10.1152/physrev.00004.2003

H. M. Wu, Y. M. Yang, and S. G. Kim, Rimonabant, a cannabinoid receptor type 1 inverse agonist, inhibits hepatocyte lipogenesis by activating liver kinase B1 and AMP-activated protein kinase axis downstream of Galpha i/o inhibition, Mol Pharmacol, issue.5, pp.80-859, 2011.

A. Karvela, Endocannabinoid (EC) Receptor, CB1, and EC Enzymes' Expression in Primary Adipocyte Cultures of Lean and Obese Pre-pubertal Children in Relation to Adiponectin and Insulin, Journal of Pediatric Endocrinology and Metabolism, vol.23, issue.10, pp.23-1011, 2010.
DOI : 10.1515/jpem.2010.162

A. C. Howlett, International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors, Pharmacological Reviews, vol.54, issue.2, pp.161-202, 2002.
DOI : 10.1124/pr.54.2.161

M. T. Viscomi, The endocannabinoid system: A new entry in remote cell death mechanisms, Experimental Neurology, vol.224, issue.1, pp.56-65, 2010.
DOI : 10.1016/j.expneurol.2010.03.023

H. Sharir and M. E. Abood, Pharmacological characterization of GPR55, a putative cannabinoid receptor, Pharmacology & Therapeutics, vol.126, issue.3, pp.301-314, 2010.
DOI : 10.1016/j.pharmthera.2010.02.004

C. M. Henstridge, Off-Target Cannabinoid Effects Mediated by GPR55, Pharmacology, vol.89, issue.3-4, pp.179-87, 2012.
DOI : 10.1159/000336872

H. Sharir, The Endocannabinoids Anandamide and Virodhamine Modulate the Activity of the Candidate Cannabinoid Receptor GPR55, Journal of Neuroimmune Pharmacology, vol.284, issue.18, 2012.
DOI : 10.1007/s11481-012-9351-6

E. Manira, A. , and A. Kyriakatos, The Role of Endocannabinoid Signaling in Motor Control, Physiology, vol.25, issue.4, pp.230-238, 2010.
DOI : 10.1152/physiol.00007.2010

E. M. Berry and R. Mechoulam, Tetrahydrocannabinol and endocannabinoids in feeding and appetite, Pharmacology & Therapeutics, vol.95, issue.2, pp.185-90, 2002.
DOI : 10.1016/S0163-7258(02)00257-7

A. H. Taylor, Endocannabinoids and pregnancy, Clinica Chimica Acta, vol.411, issue.13-14, pp.13-14, 2010.
DOI : 10.1016/j.cca.2010.03.012

M. R. Tramer, Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic, BMJ, vol.323, issue.7303, pp.323-339, 2001.
DOI : 10.1136/bmj.323.7303.16

J. Guindon and A. G. Hohmann, The Endocannabinoid System and Pain, CNS & Neurological Disorders - Drug Targets, vol.8, issue.6, pp.403-424, 2009.
DOI : 10.2174/187152709789824660

M. A. Jorda, Hematopoietic cells expressing the peripheral cannabinoid receptor migrate in response to the endocannabinoid 2-arachidonoylglycerol, Blood, issue.8, pp.99-2786, 2002.

G. J. Maestroni, The endogenous cannabinoid 2-arachidonoyl glycerol as in vivo chemoattractant for dendritic cells and adjuvant for Th1 response to a soluble protein, The FASEB Journal, issue.15, pp.18-1914, 2004.
DOI : 10.1096/fj.04-2190fje

H. Schwarz, F. J. Blanco, and M. Lotz, Anadamide, an endogenous cannabinoid receptor agonist inhibits lymphocyte proliferation and induces apoptosis, Journal of Neuroimmunology, vol.55, issue.1, pp.107-122, 1994.
DOI : 10.1016/0165-5728(94)90152-X

M. T. Cencioni, Anandamide Suppresses Proliferation and Cytokine Release from Primary Human T-Lymphocytes Mainly via CB2 Receptors, PLoS ONE, vol.5, issue.1, p.8688, 2010.
DOI : 10.1371/journal.pone.0008688.t003
URL : http://doi.org/10.1371/journal.pone.0008688

T. W. Klein, Delta 9-tetrahydrocannabinol treatment suppresses immunity and early IFN-gamma, IL-12, and IL-12 receptor beta 2 responses to Legionella pneumophila infection, J Immunol, issue.12, pp.164-6461, 2000.

L. X. Zhu, ??-9-Tetrahydrocannabinol Inhibits Antitumor Immunity by a CB2 Receptor-Mediated, Cytokine-Dependent Pathway, The Journal of Immunology, vol.165, issue.1, pp.373-80, 2000.
DOI : 10.4049/jimmunol.165.1.373

T. W. Klein, Cannabinoid-based drugs as anti-inflammatory therapeutics, Nature Reviews Immunology, vol.267, issue.5, pp.400-411, 2005.
DOI : 10.1002/glia.10177

J. Killestein, Immunomodulatory effects of orally administered cannabinoids in multiple sclerosis, Journal of Neuroimmunology, vol.137, issue.1-2, pp.140-143, 2003.
DOI : 10.1016/S0165-5728(03)00045-6

S. Hart, O. M. Fischer, and A. Ullrich, Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor, Cancer Res, issue.6, pp.64-1943, 2004.

S. Kishimoto, 2-Arachidonoylglycerol, an Endogenous Cannabinoid Receptor Ligand, Induces Accelerated Production of Chemokines in HL-60 Cells, Journal of Biochemistry, vol.135, issue.4, pp.517-541, 2004.
DOI : 10.1093/jb/mvh063

T. Sugiura, New Perspectives in the Studies on Endocannabinoid and Cannabis: 2-Arachidonoylglycerol as a Possible Novel Mediator of Inflammation, Journal of Pharmacological Sciences, vol.96, issue.4, pp.367-75, 2004.
DOI : 10.1254/jphs.FMJ04003X3

A. Cerwenka and L. L. Lanier, Natural killer cells, viruses and cancer, Nature Reviews Immunology, vol.31, issue.1, pp.41-50, 2001.
DOI : 10.1038/35095564

R. P. Wallin, Regulation of perforin-independent NK cell-mediated cytotoxicity, European Journal of Immunology, vol.33, issue.10
DOI : 10.1002/eji.200324070

M. Blery, Reconstituted killer cell inhibitory receptors for major histocompatibility complex class I molecules control mast cell activation induced via immunoreceptor tyrosine-based activation motifs, J Biol Chem, issue.14, pp.272-8989, 1997.

N. Stanietsky and O. Mandelboim, Paired NK cell receptors controlling NK cytotoxicity, FEBS Letters, vol.156, issue.24, pp.4895-900, 2010.
DOI : 10.1016/j.febslet.2010.08.047

J. A. Gracie, S. E. Robertson, and I. B. Mcinnes, Interleukin-18, Journal of Leukocyte Biology, vol.73, issue.2, pp.213-237, 2003.
DOI : 10.1189/jlb.0602313

F. Kuttler, Relationship between expression of genes involved in cell cycle control and apoptosis in diffuse large B cell lymphoma: a preferential survivin???cyclin B link, Leukemia, vol.16, issue.4, pp.726-761, 2002.
DOI : 10.1038/sj.leu.2402427

Y. Hayakawa, IFN-gamma-mediated inhibition of tumor angiogenesis by natural killer T-cell ligand, alpha-galactosylceramide, Blood, vol.100, issue.5, pp.1728-1761, 2002.

M. A. Cooper, Cytokine-induced memory-like natural killer cells, Proceedings of the National Academy of Sciences, vol.106, issue.6, pp.1915-1924, 2009.
DOI : 10.1073/pnas.0813192106
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644138

M. Cella, A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity, Nature, vol.3, issue.7230, pp.457-722, 2009.
DOI : 10.1038/nature07537

K. Hellstrand and S. Hermodsson, An Immunopharmacological Analysis of Adrenaline-Induced Suppression of Human Natural Killer Cell Cytotoxicity, International Archives of Allergy and Immunology, vol.89, issue.4, pp.334-375, 1989.
DOI : 10.1159/000234972

K. Hellstrand, S. Hermodsson, and O. Strannegard, Evidence for a betaadrenoceptor-mediated regulation of human natural killer cells, J Immunol, vol.134, issue.6, pp.4095-4104, 1985.

M. Bouaboula, Cannabinoid-receptor expression in human leukocytes, European Journal of Biochemistry, vol.132, issue.1, pp.173-80, 1993.
DOI : 10.1016/0003-2697(78)90327-5

S. Galiegue, Expression of Central and Peripheral Cannabinoid Receptors in Human Immune Tissues and Leukocyte Subpopulations, European Journal of Biochemistry, vol.23, issue.1, pp.54-61, 1995.
DOI : 10.1016/0165-3806(93)90124-S

M. A. Cooper, T. A. Fehniger, and M. A. Caligiuri, The biology of human natural killer-cell subsets, Trends in Immunology, vol.22, issue.11, pp.22-633, 2001.
DOI : 10.1016/S1471-4906(01)02060-9

Y. Daaka, -Tetrahydrocannabinol Is Mediated by Nuclear Factor ??B and CB1 Cannabinoid Receptor, DNA and Cell Biology, vol.16, issue.3, pp.301-310, 1997.
DOI : 10.1089/dna.1997.16.301

S. Kishimoto, Endogenous Cannabinoid Receptor Ligand Induces the Migration of Human Natural Killer Cells, Journal of Biochemistry, vol.137, issue.2, pp.217-240, 2005.
DOI : 10.1093/jb/mvi021

D. Duluc, PolyI:C plus IL-2 or IL-12 induce IFN-gamma production by human NK cells via autocrine IFN-beta, Eur J Immunol, issue.10, pp.39-2877, 2009.

Y. T. Bryceson, A prospective evaluation of degranulation assays in the rapid diagnosis of familial hemophagocytic syndromes, Blood, vol.119, issue.12, pp.2754-63, 2012.
DOI : 10.1182/blood-2011-08-374199

D. M. Schumann, The Fas pathway is involved in pancreatic beta cell secretory function, Proceedings of the National Academy of Sciences, vol.104, issue.8, pp.2861-2867, 2007.
DOI : 10.1073/pnas.0611487104

K. H. Chi, Preclinical evaluation of locoregional delivery of radiolabeled iododeoxyuridine and thymidylate synthase inhibitor in a hepatoma model, J Nucl Med, vol.42, issue.2, pp.345-51, 2001.

L. Zamai, Natural Killer (NK) Cell???mediated Cytotoxicity: Differential Use of ???TRAIL and Fas Ligand by Immature and Mature Primary Human NK Cells, The Journal of Experimental Medicine, vol.161, issue.12, pp.188-2375, 1998.
DOI : 10.1126/science.277.5327.768

E. S. Bergmann-leitner and S. I. Abrams, Differential Role of Fas/Fas Ligand Interactions in Cytolysis of Primary and Metastatic Colon Carcinoma Cell Lines by Human Antigen-Specific CD8+ CTL, The Journal of Immunology, vol.164, issue.9, pp.4941-54, 2000.
DOI : 10.4049/jimmunol.164.9.4941

Y. Huang, Role of interleukin-18 in human natural killer cell is associated with interleukin-2, Molecular Immunology, vol.47, issue.16, pp.47-2604, 2010.
DOI : 10.1016/j.molimm.2010.05.290

C. Tecchio, IFN??-stimulated neutrophils and monocytes release a soluble form of TNF-related apoptosis-inducing ligand (TRAIL/Apo-2 ligand) displaying apoptotic activity on leukemic cells, Blood, vol.103, issue.10, pp.3837-3881, 2004.
DOI : 10.1182/blood-2003-08-2806

A. Toth, P. M. Blumberg, and J. Boczan, Chapter 15 Anandamide and the Vanilloid Receptor (TRPV1), Vitam Horm, vol.81, pp.389-419, 2009.
DOI : 10.1016/S0083-6729(09)81015-7

G. C. Baldwin, Marijuana and Cocaine Impair Alveolar Macrophage Function and Cytokine Production, American Journal of Respiratory and Critical Care Medicine, vol.156, issue.5, pp.1606-1619, 1997.
DOI : 10.1164/ajrccm.156.5.9704146

A. Ribeiro, Anandamide prior to sensitization increases cell-mediated immunity in mice, International Immunopharmacology, vol.10, issue.4, pp.431-440, 2010.
DOI : 10.1016/j.intimp.2009.12.017

A. G. Freud and M. A. Caligiuri, Human natural killer cell development, Immunological Reviews, vol.169, issue.1, pp.56-72, 2006.
DOI : 10.1073/pnas.0407522101

P. M. Zygmunt, Anandamide ??? the other side of the coin, Trends in Pharmacological Sciences, vol.21, issue.2, pp.43-47, 2000.
DOI : 10.1016/S0165-6147(99)01430-3

A. A. Zoerner, Quantification of endocannabinoids in biological systems by chromatography and mass spectrometry: A comprehensive review from an analytical and biological perspective, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, vol.1811, issue.11, pp.1811-706, 2011.
DOI : 10.1016/j.bbalip.2011.08.004

P. Carayon, Modulation and functional involvement of CB2 peripheral cannabinoid receptors during B-cell differentiation, Blood, issue.10, pp.92-3605, 1998.

J. E. Lauckner, GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current, Proceedings of the National Academy of Sciences, vol.105, issue.7, pp.2699-704, 2008.
DOI : 10.1073/pnas.0711278105

T. W. Klein, The cannabinoid system and immune modulation, Journal of Leukocyte Biology, vol.74, issue.4, pp.486-96, 2003.
DOI : 10.1189/jlb.0303101

T. W. Klein, C. Newton, and H. Friedman, Inhibition of natural killer cell function by Marijuana components, Journal of Toxicology and Environmental Health, vol.23, issue.4, pp.321-353, 1987.
DOI : 10.1084/jem.153.3.569

S. C. Specter, Marijuana effects on immunity: Suppression of human natural killer cell activity by delta-9-tetrahydrocannabinol, International Journal of Immunopharmacology, vol.8, issue.7, pp.741-746, 1986.
DOI : 10.1016/0192-0561(86)90010-X

W. Zhu, delta 9-Tetrahydrocannabinol (THC) causes the variable expression of IL2 receptor subunits, J Pharmacol Exp Ther, vol.274, issue.2, pp.1001-1008, 1995.

I. Matias and V. D. Marzo, Endocannabinoid synthesis and degradation, and their regulation in the framework of energy balance, J Endocrinol Invest, vol.29, issue.3, 2006.

A. J. Sanchez and A. Garcia-merino, Neuroprotective agents: Cannabinoids, Clinical Immunology, vol.142, issue.1, pp.57-67, 2012.
DOI : 10.1016/j.clim.2011.02.010

A. Ameri, The effects of cannabinoids on the brain, Progress in Neurobiology, vol.58, issue.4, pp.315-363, 1999.
DOI : 10.1016/S0301-0082(98)00087-2

R. N. Kumar, W. A. Chambers, and R. G. Pertwee, Pharmacological actions and therapeutic uses of cannabis and cannabinoids, Anaesthesia, issue.11, pp.56-1059, 2001.

T. P. Carr, E. D. Jesch, and A. W. Brown, Endocannabinoids, metabolic regulation, and the role of diet, Nutrition Research, vol.28, issue.10, pp.28-641, 2008.
DOI : 10.1016/j.nutres.2008.08.003

T. W. Klein, The cannabinoid system and immune modulation, Journal of Leukocyte Biology, vol.74, issue.4, pp.486-96, 2003.
DOI : 10.1189/jlb.0303101

F. Massa and K. Monory, Endocannabinoids and the gastrointestinal tract, J Endocrinol Invest, vol.29, issue.3, pp.47-57, 2006.

R. Sarzani, Endocannabinoids, Blood Pressure and the Human Heart, Journal of Neuroendocrinology, vol.26, issue.s1, pp.58-62, 2008.
DOI : 10.1016/S0140-6736(02)11911-8

D. Robbe, Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens, Proceedings of the National Academy of Sciences, vol.99, issue.12, pp.99-8384, 2002.
DOI : 10.1073/pnas.122149199

C. A. Lafourcade and B. E. Alger, Distinctions among GABAA and GABAB responses revealed by calcium channel antagonists, cannabinoids, opioids, and synaptic plasticity in rat hippocampus, Psychopharmacology, vol.410, issue.4, pp.539-588, 2008.
DOI : 10.1007/s00213-007-1040-4

R. A. Crozier, Deprivation-induced synaptic depression by distinct mechanisms in different layers of mouse visual cortex, Proceedings of the National Academy of Sciences, vol.104, issue.4, pp.1383-1391, 2007.
DOI : 10.1073/pnas.0609596104

V. A. Bender, Two Coincidence Detectors for Spike Timing-Dependent Plasticity in Somatosensory Cortex, Journal of Neuroscience, vol.26, issue.16, pp.26-4166, 2006.
DOI : 10.1523/JNEUROSCI.0176-06.2006

M. Lafourcade, Molecular Components and Functions of the Endocannabinoid System in Mouse Prefrontal Cortex, PLoS ONE, vol.30, issue.69, p.709, 2007.
DOI : 10.1371/journal.pone.0000709.t001

B. Pan, C. J. Hillard, and Q. S. Liu, Endocannabinoid signaling mediates cocaineinduced inhibitory synaptic plasticity in midbrain dopamine neurons, J Neurosci, issue.6, pp.28-1385, 2008.

C. Henneberger, S. J. Redman, and R. Grantyn, Cortical Efferent Control of Subcortical Sensory Neurons by Synaptic Disinhibition, Cerebral Cortex, vol.17, issue.9, pp.2039-2088, 2007.
DOI : 10.1093/cercor/bhl112

P. Carayon, Modulation and functional involvement of CB2 peripheral cannabinoid receptors during B-cell differentiation, Blood, issue.10, pp.92-3605, 1998.

T. W. Klein, Cannabinoid-based drugs as anti-inflammatory therapeutics, Nature Reviews Immunology, vol.267, issue.5, pp.400-411, 2005.
DOI : 10.1002/glia.10177

V. K. Pestonjamasp and S. H. Burstein, Anandamide synthesis is induced by arachidonate mobilizing agonists in cells of the immune system, Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol.1394, issue.2-3, pp.249-60, 1998.
DOI : 10.1016/S0005-2760(98)00110-6

T. Bisogno, Biosynthesis, Uptake, and Degradation of Anandamide and Palmitoylethanolamide in Leukocytes, Journal of Biological Chemistry, vol.272, issue.6, pp.3315-3338, 1997.
DOI : 10.1074/jbc.272.6.3315

D. Marzo and V. , Biosynthesis of anandamide and related acylethanolamides in mouse J774 macrophages and N18 neuroblastoma cells, Biochem J, pp.316-977, 1996.

M. Maccarrone, Human mast cells take up and hydrolyze anandamide under the control of 5-lipoxygenase and do not express cannabinoid receptors, FEBS Letters, vol.454, issue.2-3, pp.176-80, 2000.
DOI : 10.1016/S0014-5793(00)01223-0

G. Czifra, Increased expressions of cannabinoid receptor-1 and transient receptor potential vanilloid-1 in human prostate carcinoma, Journal of Cancer Research and Clinical Oncology, vol.13, issue.4, pp.507-521, 2009.
DOI : 10.1007/s00432-008-0482-3

N. Stella, Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas, Glia, vol.400, issue.Part 10, pp.1017-1047, 2010.
DOI : 10.1002/glia.20983

A. Carracedo, Cannabinoids Induce Apoptosis of Pancreatic Tumor Cells via Endoplasmic Reticulum Stress-Related Genes, Cancer Research, vol.66, issue.13, pp.66-6748, 2006.
DOI : 10.1158/0008-5472.CAN-06-0169

I. Galve-roperh, Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation, Nat Med, vol.6, issue.3, pp.313-322, 2000.

G. Velasco, Cannabinoids and ceramide: Two lipids acting hand-by-hand, Life Sciences, vol.77, issue.14, pp.1723-1754, 2005.
DOI : 10.1016/j.lfs.2005.05.015

S. Demorrow, The endocannabinoid anandamide inhibits cholangiocarcinoma growth via activation of the noncanonical Wnt signaling pathway, AJP: Gastrointestinal and Liver Physiology, vol.295, issue.6, pp.295-1150, 2008.
DOI : 10.1152/ajpgi.90455.2008

P. Massi, Antitumor Effects of Cannabidiol, a Nonpsychoactive Cannabinoid, on Human Glioma Cell Lines, Journal of Pharmacology and Experimental Therapeutics, vol.308, issue.3, pp.838-883, 2004.
DOI : 10.1124/jpet.103.061002

K. Nithipatikom, A new class of inhibitors of 2-arachidonoylglycerol hydrolysis and invasion of prostate cancer cells, Biochemical and Biophysical Research Communications, vol.332, issue.4, pp.1028-1061, 2005.
DOI : 10.1016/j.bbrc.2005.05.049

M. Mimeault, Anti-proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines: Implication of epidermal growth factor receptor down-regulation and ceramide production, The Prostate, vol.12, issue.1, pp.1-12, 2003.
DOI : 10.1002/pros.10190

C. Blazquez, Inhibition of tumor angiogenesis by cannabinoids, The FASEB Journal, vol.17, issue.3, pp.529-560, 2003.
DOI : 10.1096/fj.02-0795fje

C. Blazquez, Cannabinoids Inhibit the Vascular Endothelial Growth Factor Pathway in Gliomas, Cancer Research, vol.64, issue.16, pp.5617-5640, 2004.
DOI : 10.1158/0008-5472.CAN-03-3927

S. Hart, O. M. Fischer, and A. Ullrich, Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor, Cancer Res, issue.6, pp.64-1943, 2004.

R. J. Mckallip, M. Nagarkatti, and P. S. Nagarkatti, ??-9-Tetrahydrocannabinol Enhances Breast Cancer Growth and Metastasis by Suppression of the Antitumor Immune Response, The Journal of Immunology, vol.174, issue.6, pp.3281-3290, 2005.
DOI : 10.4049/jimmunol.174.6.3281