Association Between Baseline Hemodynamic Indices, Cardiotoxicity Risk and Survival in Women with Breast Cancer

Charles-Edouard Decorads (1, 2) , Aurélien Lambert (3) , Véronique Roch (1, 2) , Laetitia Imbert (1, 2, 4) , Mathieu Perrin (1, 2) , Marine Claudin (1, 2) , Matthieu Doyen (4) , Quentin Citerne (1, 2) , Zohra Lamiral (5) , Didier Peiffert (3) , Catherine Henneton (3) , Pierre-Yves Marie (1, 2, 6)

1 Nancyclotep- Experimental Imaging Platform = Plate-forme d'imagerie moléculaire
2 Service de Médecine Nucléaire [CHRU Nancy]
3 UNICANCER/ICL - Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy]
4 IADI - Imagerie Adaptative Diagnostique et Interventionnelle
5 CIC - Centre d'investigation clinique [Nancy]
6 DCAC - Défaillance Cardiovasculaire Aiguë et Chronique

In a cohort of 274 women breast cancer women who were monitored by equilibrium radionuclide angiography for potentially cardiotoxic drugs (anthracyclines or trastuzumab) and who had no history of cardiac disease and a normal left ventricular ejection fraction before treatment, baseline indexes based on heart-rate/blood pressure ratios unmask hemodynamic profiles strongly associated with an increased risk of cardiotoxicity and subsequently decreased survival. Although further validations in other cohorts are needed, these findings highlight the need for a more comprehensive assessment of the cardiac- and vascular-related risk in breast cancer women monitored by equilibrium radionuclide angiography.

Mots clés: equilibrium radionuclide angiography breast cancer cardiotoxicity hemodynamics shock index; equilibrium radionuclide angiography; breast cancer; cardiotoxicity; hemodynamics; shock index

Domaines: Sciences du Vivant [q-bio]

Charles-Edouard Decorads, Aurélien Lambert, Véronique Roch, Laetitia Imbert, Mathieu Perrin, et al.. Association Between Baseline Hemodynamic Indices, Cardiotoxicity Risk and Survival in Women with Breast Cancer. Journal of Nuclear Cardiology, inPress, pp.101849. ⟨10.1016/j.nuclcard.2024.101849⟩. ⟨hal-04517441⟩