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Superacid and thiol-ene reactions for access to psammaplin analogues with HDAC inhibition activities

Abstract : An innovative synthesis of psammaplin-like structure is proposed based on original methodologies using superacid, microwaves, and S-ene chemistry. The new compounds were evaluated as histone deacetylase inhibitors. The results highlight important considerations when using disulfide prodrugs activated under reductive/oxidative conditions that must be carefully selected depending on tumor cell types
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https://hal.archives-ouvertes.fr/hal-01314516
Contributor : Dominique Martin Connect in order to contact the contributor
Submitted on : Wednesday, May 11, 2016 - 3:10:01 PM
Last modification on : Tuesday, September 27, 2022 - 4:08:49 AM

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Fatima El Bahhaj, Jerome Desire, Christophe Blanquart, Nadine Martinet, Vincent Zwick, et al.. Superacid and thiol-ene reactions for access to psammaplin analogues with HDAC inhibition activities . Tetrahedron, Elsevier, 2014, 70 (51 ), pp.9702-9708 ⟨10.1016/j.tet.2014.10.053⟩. ⟨hal-01314516⟩

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