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The conflict between treatment optimization and registration of radiopharmaceuticals with fixed activity posology in oncological nuclear medicine therapy

Abstract : The “intended purpose” in all therapeutic exposures is treatment efficacy against malignant disease. The optimization principle (as low as reasonably achievable, ALARA) of article 56, when applied in a therapy situation, states that absorbed doses to nontarget tissues should be kept reasonably low, but not so low as to lose efficacy. We think that this applies above all to the fight against life-threatening cancer. As a consequence, we believe that to adhere to the optimization principle in oncological patients, nuclear medicine therapy should be based on individualized dosimetry.
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https://hal.umontpellier.fr/hal-02379748
Contributor : Nathalie Salvy-Córdoba Connect in order to contact the contributor
Submitted on : Monday, November 25, 2019 - 6:31:56 PM
Last modification on : Thursday, September 1, 2022 - 11:10:59 AM

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C. Chiesa, K. Sjogreen Gleisner, G. Flux, J. Gear, S. Walrand, et al.. The conflict between treatment optimization and registration of radiopharmaceuticals with fixed activity posology in oncological nuclear medicine therapy. European Journal of Nuclear Medicine and Molecular Imaging, Springer Verlag (Germany), 2017, 44 (11), pp.1783-1786. ⟨10.1007/s00259-017-3707-3⟩. ⟨hal-02379748⟩

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